9. Biomolecular Engineering: Engineering of Immunity

Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman talks about the importance of vaccines, and particularly the role of bioengineering in vaccine development. He first addresses the question of “what is a vaccine” and the role of the immune system. He then describes the biological basis, symptoms, and history of smallpox as a devastating disease worldwide, and how–starting with the work of Edward Jenner–an effective vaccine was systematically developed from cow lesions. Next, methods to deliver vaccine to a wide population are introduced. Finally, Professor Saltzman touches on the possible reemergence of smallpox as weapon for bioterrorism.

00:00 – Chapter 1. Introduction
04:42 – Chapter 2. Vaccine
13:56 – Chapter 3. Smallpox and History of Early Vaccine Development
29:05 – Chapter 4. History of Modern Smallpox Vaccinations
41:27 – Chapter 5. Threat of Bioterrorism and Conclusion

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.